Plasma surface modification of nanostructured surfaces of marine based scaffolds and membranes for enhanced bioactivity.

Prof. Jayakumar Rangasamy

  • Project code : BT/PR13585/NNT/28/474/2010
  • Designation : Professor
  • Department :Amrita Center for Nanosciences and Molecular Medicine
  • Affiliation : Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi-682041, Kerala
  • Email Id :rjayakumar@aims.amrita.edu
  • Sanctioned Amt :Rs. 44,31,016/-
  • Sanctioned Date :2010-09-15
  • Completion Date :2013-09-15
  • Web Url : https://www.amrita.edu/faculty/dr-jayakumar-rangasamy
  • Project Status :Completed

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Objectives of the Study

1. Surface modification of the developed marine based nanobiomaterials by plasma treatment and their surface characterization. 

2. Development of novel marine based nanocomoposite scaffolds and membranes for bone and skin tissue engineering applications and their physico-chemical characterization. 
 3. Assessment of biocompatibility of the marine based nanocomposite scaffolds and membranes with and without plasma treatment .
 4. Influence of surface modification on cellular adhesion, proliferation and differentiation in vitro as well as in vivo.

Proposed outcomes of the study

Controlled delivery of PTH 1-34 peptide either systemic or oral using chitosan particles as a carrier will have high impact i.e. reduced time course and no painful for treating bone diseases such as osteoporosis and bone-related diseases such as breast cancer- and prostate cancer- induced bone metastasis or osteolysis.

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