Propeller shaped nano-particles and nano-structured surfaces for applications in biotechnology.

Dr. Ambarish Ghosh * Verified.

  • Project code : BT/PR12869/NNT/28/447/2009
  • Designation :Associate Professor
  • Department :Center for Nanoscience and Engineering
  • Affiliation :Indian Institute of Science, Bangalore
  • Contact No. :+91-8022932442
  • Email Id :ambarish@iisc.ac.in
  • Sanctioned Amt :Rs. 1,61,22,024/-
  • Sanctioned Date :2010-05-21
  • Completion Date :2016-05-21
  • Web Url : http://www.cense.iisc.ac.in/ambarish/

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Summary of The Proposed Outcome.

In the proposed project, we hope to develop a system of glass nano-propellers in the size range from 100 nm to few microns, which are one to two orders of magnitude smaller than existing technologies. The small size is essential for their simultaneous functionality as "active and passive" probes, and will have substantially long sedimentation time, which is essential from the perspetive of suggested applications. From the material aspect, glass (SiO2) provides an excellent platform for conjugating biomolecules via standadrd surface (silane) chemistry methods. A thin ferromagnetic coating on these nano-strucutres is expected to be bio-compatible while allowing them to be propelled (non-locally) by homogeneous magnetic fields in a cork- screw type motion. We beleive that the proposed system of nano-propeller can become an important tool in a variety of biotechnological applications, such as rheological measurements, pathogen sensing techniques and targeted chemical delivery.

Outcomes.

Nanoswimmers the idea of tiny vessels roaming around in human blood vessels working as surgical nanorobots captured the imagination of scientists and non-scientists alike. Such multifunctional nanoswimmers may have fascinating applications in diagnosing and treating diseases in live subjects, and could revolutionize medicinal practices some day. At IISc, Bengaluru, a system of artificial nanostructures was developed that can be maneuvered remotely in bodily fluids, such as human blood, using small magnetic fields. The method mimics the motion of E-Coli bacteria, which achieves directional motion by the rotation of helical flagella. While natural biological swimmers are internally (chemically) powered, the present system of magnetized helical nanostructures is powered and maneuvered by externally applied rotating magnetic fields. The spatial control can be better than a micron, and it is possible to conjugate bio-chemicals, such as drug molecules to the nanoswimmers using standard chemistry protocols.

Publication.

1    Arijit Ghosh, Debadrita Paria, Haobijam Johnson Singh, Pooyath Lekshmy Venugopalan, and Ambarish Ghosh Dynamical configurations and bistability of helical nanostructures under external torque Physical Review E 2012, 86, 031401

2    Arijit Ghosh, Pranay Mandal, Suman Karmakar and Ambarish Ghosh Analytical theory and stability analysis of an elongated nanoscale object under external torque Physical Chemistry Chemical Physics 2013, 15, 10817-10823

3    Haobijam Johnson Singh and Ambarish Ghosh Porous Three Dimensional Arrays of Plasmonic Nanoparticles Journal of Physical Chemistry C 2012, 116, 19467-19471

4    Johnson Haobijam Singh, Greshma Nair, Arijit Ghosh and Ambarish Ghosh Wafer scale fabrication of porous three-dimensional plasmonic metamaterials for the visible region: chiral and beyond Nanoscale 2013, 5, 7224-7228

5    Peer Fischera and Ambarish Ghosh Magnetically actuated propulsion at low Reynolds numbers: towards nanoscale control Nanoscale 2011, 3, 557-563

6    Pooyath Lekshmy Venugopalan, Gaurav Gupta, Arijit Ghosh, Haobijam Johnson Singh ,Greshma Nair and Ambarish Ghosh Study of the Formation of Nano-Networks in Colloidal Particles International Journal of Polymeric Materials and Polymeric Biomaterials 2013, 62, 499-501

7    Rajitha Papukutty Rajan and Ambarish Ghosh Angular amplification by a diffraction grating for chiro-optical measurements Applied Optics 2012, 51, 6480-6483

8    Rajitha Papukutty Rajan and Ambarish Ghosh Enhancement of circular differential deflection of light in an optically active medium Optics Letters 2012, 37, 1232-1234

Patent

1    Ambarish Ghosh and Haobijam J Singh An assembly of plasmonic nanostructures for enhanced detection of chemical groups. Indian Patent Application No. 1979/CHE/2012 filed on 18/05/2012 and published on 22/11/2013. 2012, ,

Technology Transferred

Human Resources

2 RA