Plasma surface modification of nanostructured surfaces of marine based scaffolds and membranes for enhanced bioactivity.

Prof. Jayakumar Rangasamy * Verified.

  • Project code : BT/PR13585/NNT/28/474/2010
  • Designation :Professor
  • Department :Amrita Center for Nanosciences and Molecular Medicine
  • Affiliation :Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi-682041, Kerala
  • Email Id :rjayakumar@aims.amrita.edu
  • Sanctioned Amt :Rs. 44,31,016/-
  • Sanctioned Date :2010-09-15
  • Completion Date :2013-09-15
  • Web Url : https://www.amrita.edu/faculty/dr-jayakumar-rangasamy

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Summary of The Proposed Outcome.

Controlled delivery of PTH 1-34 peptide either systemic or oral using chitosan particles as a carrier will have high impact i.e. reduced time course and no painful for treating bone diseases such as osteoporosis and bone-related diseases such as breast cancer- and prostate cancer- induced bone metastasis or osteolysis.

Outcomes.

In continuation of the ongoing research efforts at AIMS, Kochi, various marine based polymeric scaffolds were fabricated and combination of argon and nitrogen plasma treatment was carried out to improve its bio-responsiveness. The developed chitin/PHBV and chitin/PCL/ nCS scaffolds showed enhanced hydrophilicity, protein adsorption, cell attachment and proliferation. The addition of polar functional groups on the fibers by plasma treatment modified its property from hydrophobic to hydrophilic nature thereby increasing the applicability of this material. Protein adsorption was also enhanced. The developed membrane would prove beneficial for tendon tissue engineering after plasma treatment.

Publication.

1     Deepthi, S. et al. 2015, ,

2     Deepthi Sankar, K.P. Chennazhi, Suseela Mathew, R.Jayakumar. "Functionally and topographically tailored poly (caprolactone)/collagen multiscale fibrous scaffold as tendon construct. RSC Advances, 2015, Accepted with major revision(IF:3.71)" 2015, ,

3    Deepthi Sankar, K. P. Chennazhi, Shantikumar V. Nair and R. Jayakumar Fabrication of chitin/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) hydrogel scaffold Carbohydrate Polymers 2012, 90, 725-729

4    Deepthi Sankar, K.T. Shalumon, K.P. Chennazhi, Deepthy Menon and R. Jayakumar Micro, Nano, and Multiscale Fibrous Scaffolds for Enhanced Osteoconductivity Tissue Engineering Part A 2014, 20, 1689-1702

5    Kavya K. C., Dixit Rachna, Jayakumar R., Nair Shantikumar V. and Chennazhi Krishna Prasad Synthesis and Characterization of Chitosan/Chondroitin Sulfate/Nano-SiO2 Composite Scaffold for Bone Tissue Engineering Journal of Biomedical Nanotechnology 2012, 8, 149-160

6    Shalumon K. T., Sathish D., Nair S. V., Chennazhi K. P., Tamura H. and Jayakumar R. Fabrication of Aligned Poly(Lactic Acid)-Chitosan Nanofibers by Novel Parallel Blade Collector Method for Skin Tissue Engineering Journal of Biomedical Nanotechnology 2012, 8, 405-416

7    Shalumon K. T., Sowmya S., Sathish D., Chennazhi K. P., Nair Shantikumar V. and Jayakumar R. Effect of Incorporation of Nanoscale Bioactive Glass and Hydroxyapatite in PCL/Chitosan Nanofibers for Bone and Periodontal Tissue Engineering Journal of Biomedical Nanotechnology 2013, 9, 430-440

8    Sowmya Srinivasan, R. Jayasree, K. P. Chennazhi, S. V. Nair and R. Jayakumar Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration Carbohydrate Polymers 2012, 87, 274-283

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